Protein - mediated Uptake of Vitamin 12 by Isolated Mitochondria

Protein-mediated B12 uptake by isolated respiration. Following uptake, cyanorat liver mitochondria has been shown to cobalamin is converted to adenosyl and be enhanced by plasma transcobalamin methylcobalamins and released from the (TC-lI) but not by salivary R binder in mitochondria. TC-ll appears to be required vitro. The process is enhanced by calcium for both cellular and mitochondrial uptake and depends on active mitochondrial of vitamin B12.